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doi: 10.1016/j.aca.2012.03.056

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However, environmental factors are required for the development of manifest disease

Mechanistically, CX-5461 modulates CD36-ACSL4-mediated glycerophospholipid metabolism in B cells, triggers ferroptosis via the p53-SLC7A11- Arachidonate 12-Lipoxygenase (ALOX12) pathway and lowers IgG and anti-dsDNA antibody levels, thus attenuating lupus pathogenesis